EFTA02100786

To: Joseph Thakuri. Cc: Rich Kahn From: Sent: Mon 3/3/2014 5:28:18 PM Subject: Re: Jeffrey Epstein sure...I have passed along On Mar 3, 2014, at 12:13 PM, Joseph Thakuria wrote: Thanks, if you could also pass on to Jeffrey: The Y PO folks arc also awaiting this NIGH IRB approval along with him for work beyond the DNA extraction. They will nccd to get rc-consented and may even nccd to resubmit samples under the new protocol. Assuming it goes through, they will have their exomes sequenced while Jeffrey will have his full genome sequenced. Joe Thakuria On Sun, Mar 2, 2014 at 10:53 AM, Hi Joe...I have passed along to JetTrey..thanks! On Mar 1, 2014, at 2:41 PM, Joseph Thakuria wrote: wrote: Hi Richard, my study is still awaiting irb approval at mgh. Once that goes through, there'll be a consent form for Jeffrey to review and sign and then I can forward the invoice from Illumina for the rapid turn-around-time whole genome. Once we have his data and go through the analyses Illumina provides, I can discuss with him any extra value from using additional tools for analyses. The irb approval process will take 3-5 weeks in the best case scenario. As a physician, I could just order it for him from Illumina but Jeffrey and I agreed the research route made the most sense. For one, ordering a whole genome on a (presumably) healthy patient is not currently indicated. Doing this as a patient (at least at mgh) would also entail creating a medical record of the encounter and the results. Our plan is to keep this data private - at least until he's had a chance to review with me. So, for this reason, we also agreed to go the "research study" route with his genome. I've discussed doing Jeffrey's genome through my mgh study with george church and he's fine with it. I'll coordinate getting JE's samples from the pgp and moving all of it, or a portion EFTA_R1_00708486 EFTA02100786 (aliquots of the dna and cell lines) to the new study (again, after the mgh study is formally approved - that's the bottleneck now). with Jeffrey not on the cc, please pass the info above on to him. Let me know if he has any questions. I can clarify anything by email or phone. Maybe there was a misunderstanding when I mentioned the 'rapid turnaround time' offering from illumina? This just means illumina's role - the sequencing of the sample - is expedited. There is no way, unfortunately, to expedite the MGH IRB process for approving human research studies. (A lot of us wish there was!) Joe Thakuria Jose.h V. Thakuria MD, MMSc E FTA_R 1_00708487 EFTA02100787