From: Faculty of 1000 ct=l

From: Faculty of 1000 ct=l > To: Jeff Epstein <jeeproject®yahoo.com> Subject: Faculty of 1000 Monthly Update - November 2010 Date: Tue, 16 Nov 2010 15:20:12 +0000 If you're having trouble viewing this message, click to view in your default browser Advert 2,F1000 Monthly Update Evaluations Rankings Reports Posters Magazine Faculty November 2010 Widow Editor's n Choice 6 ‘1 OWF I 000 n Features Editor's Choice main article Cell Biology: Gateway to the cilium A cell's "for cilia only" address label. L,,r'clow Top ;Nlow F1000 n 7 n Posters Immunology: Gut reactions Can gut bacteria influence arthritis? Cell Biology: Biosensor beacon Spider silk protein is used as a molecular spring to measure tension in cell adhesion. Hidden Jewel: Infection plagues IQ? Fighting infections saps energy from developing brain. F1000 Features main article Heads and Tales Randall Moon has looked to tadpoles and stem cells for clues about embryonic development and cell fate. Now he has his eye on turning Cancer's Conversions A process at the heart of gastrulation in the developing embryo may be a useful model for tumor progression. By Nancy Gavert and Airi Ben-ZetEr. LQR One on One: Genome Blossoms Pioneering genome cell biologist Tont Misteli on chromatin organization and the most detailed 3- D model of a eukaryotic genome reported to date. Thought Experiment On Plasmids: Genome synthesis for the rest of us. Directed evolution of entire genomes might not be the best way to generate new function. By Andrew Ellington. ;Ifaceb2i W k ;your ok link — ed-in ter ube link link link New this Month 1,096 Evaluations added 7 Articles that Change Clinical Practice 2 Articles with Dissents Paw on f1OOO.com Current Issue ;latest issue Driving Self-Recognition More titan 30,000 different proteins generated by one gene are part of an entirely unexpected signaling mechanism that guides growing neurons. Elemental Shortage The world is running out of cheap phosphorus, just as biologists are EFTA00779903 biology into therapy. By Karen Hopkin. beginning to understand the role it plays in evolution and human health. Ili middle advert Top 7 Evaluated Articles 1 How cilia talk Primary (non-motile) cilia use membrane proteins in their role as a coordinator of the cell's signaling pathways. New findings show how a cilium retains those membrane proteins - a barrier at its base made up of proteins called septins. 2 To stent or not? A large randomized trial demonstrates that stenting and surgical clearing of arteries are safe and equally effective ways of treating the narrowing of the carotid arteries, called stenosis. 3 Diabetes dilemmas This clinical trial demonstrates that two popular high blood pressure drugs had no effect on progressive kidney damage, but did slow degeneration of the retina - two complications of Type 1 diabetes. 4 One path to obesity The authors report a novel mechanism by which a high-fat diet can alter the expression of a large number of obesity-associated genes, suggesting new approaches to treating obesity and insulin resistance. 5 Coat structures Crystallographic analyses of subunits of the COPI coat - a critical structure for the transport of protein-filled vesicles from the Golgi back to the endoplasmic reticulum - reveal similarities to two other major vesicle coats in the cell, suggesting a common origin for this type of structural protein. 6 Sensing tension This study demonstrates a molecular mechanism for how adherens junctions - protein complexes that occur at cell-cell junctions in epithelial tissues - sense and respond to mechanical forces in the cell. 7 Monitoring patients Monitoring patients after surgery using pulse oximetry, which measures the oxygenation of arterial blood, can improve patient outcomes and lower overall health-care costs by reducing the number of emergency resuscitations and trips to the intensive care unit. This FI000 Top 7 is a snapshot of the highest-ranked articles front a 30-day period in the previous month, described by The Scientist reporting team. See also Top 7s in Neuroscience, Developmental Biology, Immunology, Cell Biology, Hidden Jewels. To see the latest rankings, visit http://F1000.comf Life Sciences Salary Survey 2010 Scientists are making the most of their careers despite dropping salaries and rising lab costs. Naturally Selected video preview image David Nutt talks about his work at Imperial College studying the 21 molecular underpinnings of addiction. Recommend a Free 30-day Trial to your Librarian You can use our online form to send your recommendation. Alternatively, you may qualify for free access via HINARI or Faculty Member sponsorship. EFTA00779904 F1000 Posters toR Poster of the month iievaluated poster Neurological Disorders An immunotherapeutic strategy targeting neurotoxicity of tPA: A new hope for the treatment of stroke Macrez et al. Based on: International Symposium on Neuroprotection and Neurorepair 2010. Summary I Poster View our latest submissions, including from the recent: World Congress on Pain 2010 European Respiratory Society 2010 meeting Human Proteome Organisation 2010 meeting g'.&posit a poster You have received this message because you asked to receive updates from Faculty of 1000. Your registered email address is: jeeproject©yahoo.com. If you do not wish to receive any further messages, you may unsubscribe at any time. Please send a blank email to with 'Unsubscribe in the subject line. For thither information or enquiries please contact Customer Services at F1000, Faculty of 1000 Ltd I Science Navigation Group I Registered in England and Wales with Company Number 3739756 Middlesex House, 34-42 Cleveland Street I London, WIT 4LB I United Kingdom EFTA00779905