Cannabis Investment Report – Basic Endocannabinoid Overview

KR L PI L AC EL CA TA Cannabis Investment Report | December 2017 = The Human Endocannabinoid System The human endocannabinoid system consists of nervous and immune system receptors involved in regulating health and physiological functions. There are two types of endocannabinoid receptors, CB1 and CB2 receptors, which are located in the brain and in other organs, tissues and glands throughout the human body. The human body actively regulates variables related to appetite, immune response, memory, mood, pain, sleep and other functions by naturally creating compounds known as “endo- cannabinoids” and delivering them to these receptors. The following illustration depicts the human endocannabinoid system and the location of CB1 and CB2 receptors. Human Endocannabinoid System CB1 Receptors CB2 Receptors Immune Cells ce cee ' CB1 and CB2 Brain Spleen Immune system Lungs Bones Liver Vascular system Skin Bone marrow Muscles Glial cells Pancreas Gastrointestinal tract Brain stem Reproductive organs The physiological effects of cannabis consumption are believed to be primarily the result of THC, CBD and other cannabinoids bonding with the body’s endocannabinoid receptors and the consequent impact on functions regulated by the endocannabinoid system. As scientists gain a deeper understand- ing of the human endocannabinoid system, they are beginning to explore the application of cannabi- noids to a broad range of medical conditions and ailments. Although medical research on cannabinoids is nascent, cannabis is currently being used to manage many conditions, including anxiety, depression, inflammation, insomnia, nausea, neural disorders and pain. CB1 and CB2 Receptors CB1 and CB2 endocannabinoid receptors, which are found on cell surfaces throughout the body, are believed to be more numerous than any other cellular receptor signaling system in the human body. The CB1 receptors are located primarily in the brain, central nervous system and other tissues; these receptors play a modulatory role in memory, mood, sleep, appetite and pain sensation. The CB2 recep- 18 © 2017 Ackrell Capital, LLC | Member FINRA/SIPC HOUSE_OVERSIGHT_024654