EFTA01888372

To: Epstein Jeffreylieevacationagmailcomj From: Lesley Groff Sent Mon 9/10/2012 7:15:40 PM Subject: Fwd: Dinochicken meeting proposal Please sec below from Jack Homer ...I do not see anything on the calendar for Oct. 25/26 Bobby Slayton will be in NY Oct 15/16 and wants to have the dinner party on 16th Notice of Special Hearing in the Rothstein, Edwards case at 9:45am on Oct. 22nd in PB Julian Leese shooting in Suffcx Oct. 29th (he wants JE to be there) Begin forwarded message: From: Jack Horne Subject: Re: Dinoc is ten mee mg proposa Date: September 10 2012 3 00 15 PM EDT To: Lesley Groff Hi Jeffrey, I've conducted the Doodle Poll and everyone is interested in getting together sooner rather than later, so we are looking at October 24-25. I'm wondering if you would be able to help with finding this "Dinochicken Summit" and what you would need from me. Also would very much like for you to be here if its at all possible, as you could then see what all is known and what is not. All the best, Jack On Scp 1, 2012, at 11:13 AM, Lesley Groff wrote: You as well Sent from my iPhone On Sep 1, 2012, at 12:53 PM, Jack Home Thanks Lesley, much appreciated! Have a great weekend! Jack On Sep 1, 2012, at 10:38 AM, Lesley Groff wrote: wrote: EFTA_R1_00300171 EFTA01888372 Thank you!! Passing this on to Jeffrey. Sent from my iPhone On Sep 1, 2012, at 12:18 PM, Jack Homer wrote: Dear Jeffrey, First off, many thanks for the invitation to your ranch, I had a great time, especially spending time with you and the girls, and seeing your Cretaceous sediments and the old railroad. I don't get many chances to spend time with non paleontologists or see places and things like that these days. I talked to my post dots and Co- PI when I returned and got the scoop on the transgenic chickens situation, for as you know I was very surprised to hear that such a thing existed since my co-researchers were saying they didn't. As it turns out, although there are such a thing, there is simply no established protocol to create them, and they, at present do not pass on their characteristics, so in effect are useless for our project. What it is that we need to do is to be able to target a specific region of DNA, and that technology is not yet available in birds, but is expected within a year or two, so within our time frame. We hope someone else will do it first so we can use it, as this technology (homologous recombination technology, aka EFTA_R1_00306172 EFTA01888373 knockout technology) is essential to the success of this project. We do not aim to generate chickens that express an extraneous gene (a transgene), but we plan on finding the very small changes in the regulation of existing genes that curb tail, hand, and tooth development. In order to make these very small changes in the chicken genome, homologous recombination technology needs to be developed. Anyway, this is the sort of stuff we will discuss in our summit meeting, and I very much appreciate your considering the funding of this meeting. It is obviously the most important first step, and I thank you for suggesting we do it. Please give all the girls my very best wishes, and to you, whom I envy, Thanks again, Jack 9.1.12 Proposal Attached and Separate (attachment) <THE DINOCHICKEN PROJECT `SUMMIT' MEETING PROPOSAL.docx> EFTA R1_00306173 EFTA01888374 THE DINOCHICKEN PROJECT `SUMMIT' MEETING PROPOSAL The overall goals of the `Dinochicken Project' are to `reverse engineer' an avian dinosaur (in this case, a chicken or quail) to have morphological characteristics of a non-avian dinosaur. In its purest form, the project entails reactivating dormant or latent genetic pathways that would generate atavistic characters. The characters to be modified initially arc those identified previously as key differences between avian and non-avian dinosaurs: presence of teeth, hands/claws instead of wings, and a long true tail. A key component to any project is identifying what is already known and establishing connections with other scientists who may have relevant information already in hand. There are 6 PIs who will make the research decisions, and another 11 people who we know have expertise, and are interested in participating. The current, unpublished knowledge of these other researchers would definitely help to decide the research directions of the various PI lead teams. EFTA_R1_00306174 EFTA01888375 I am proposing to bring 12 people to Montana for the two day `summit' and we have another 5 that live here, so the meeting will include 17 research scientists plus a couple of MSU graduate students who would help with logistics. The summit meeting would be held at the Museum of the Rockies, Montana State University. Participants are currently working on Doodle.com to determine a meeting time prior to the end of 2012. The link is attached in the event that you could attend: http //doodle com/eci2xymvx8 u3t9fxs Summit Meeting Proposed Participants Montana State University Jack Horner Lead PI (Paleontologist) Christa Merzdorf Co PI (Developmental geneticist) (tail development) Anne Blackwell Post-Doc (Developmental geneticist) (tail development) EFTA_R1_00306175 EFTA01888376 Dana Rashid Post-Doc (Developmental geneticist) (tail regeneration) Dan Post-Doc (Developmental geneticist) *Two Graduate Student Assistants &n EFTA_R1_00306176 EFTA01888377