EFTA02566592

From: Ting, Jess Sent: Tuesday, February 19, 2013 10:30 PM To: Jeffrey Epstein Subject: Re: Research Our research is based on the hypothesis that it is the micro-environment (e=g., the "normal" breast tissue surrounding a breast cancer in the case of =react cancer) that enables tumors to metastasize - rather than something i=trinsic to the tumors. There is much anecdotal evidence to support this an= it also explains several paradoxes about breast cancer - for example, why=extirpative surgery for breast cancer seems to cause a paradoxical rise ca=cer activity. This theory which is known as the "seed and soil" hypothesis=has been purely theoretical in the past because until now there was never =ay to study the microenvironment around these tumors without killing the h=st or killing the tissue itself. We came up with the idea to use fluid that is routinely collected (but thro=n away) for 1-2 weeks after breast surgery as a proxy for the microenviron=ent around the tumor. Let me explain - after breast surgery to remove a c=ncerous breast, we routinely place a plastic drainage tube in the wound be= which exits the skin and drains excess blood and wound fluid into small p=astic reservoirs. This prevents buildup of unwanted blood and fluid after =urgery. This fluid is thrown away. The drains are kept in for a week or tw=. Our idea was that this fluid contains all the proteins, growth factors, =ytokines, DNA transcription factors etc that are secreted by the cells aro=nd a cancer and would make an ideal way of studying the microenvironment i= vivo. For the last three years, we have been collecting wound fluid for the first=48 hours after breast cancer surgery. We compare fluid in the same patient=from the cancerous breast to the non-cancerous breast and from the cancero=s breast to the abdomen. In certain surgeries the opposite non-cancerous b=east is removed as a precaution or tissue from the abdomen is used to reco=struct the removed breast which is why we have access this fluid from then= sites as well. This "normal" fluid is used as a control for the fluid fro= the cancerous breast. We have found differences in this fluid in both test tubes and in mice. Our=preliminary results are positive and show that this idea has validity. We =ant to continue to characterize this fluid from cancerous breasts and to c=llect more specimens. If we are successful, this will be a major advance i= understanding the mechanisms of cancer. I supported this work with my own personal research fund. I have spent $200,000 of my research fund (given to me patients) to pay for=a full time lab tech devoted to this project and for all of the supplies o=er the last three years. But my fund is down to $10,000. I have another do=ation of $100,000 coming into my fund that I will devote to this project b=t not until the end of the year. In the meantime, we would have to fire th= lab tech and stop collecting fluid specimens. To bridge the period until my research fund will be replenished with the ex=ected $100,000 grant coming at the end of the year, we would need $50,000 =ideally more for a full-court press). It could even be in the form of a lo=n that is repaid with the future contribution. Thanks for your consideration. Jess Ting On Feb 19, 2013, at 4:56 PM, "Jeffrey Epstein" <[email protected]<[email protected]» wrote: send more details EFTA_R1_01731842 EFTA02566592 On Tue, Feb 19, 2013 at 4:51 PM, Ting, Jess rote: Jeffrey, besides being a plastic surgeon, I also do basic science research =n breast cancer. My lab uses a novel approach that no one else in the worl= is doing. Our preliminary results are promising but we need funding to co=tinue to the next phase. Would you consider financially supporting us? I hope I haven't offended you by being too direct. If I have, I apologize p=ofusely. But if this is something that interests you, my lab partner and I would lov= to tell you more about it. I promise you would find it intellectually sti=ulating and interesting. Warmest regards, Jess Ting The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of Jeffrey Epstein Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected]<mailto:jeevacation@gmai=.com>, and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved <?xml version=.0" encoding=TF-8"?> <lDOCTYPE plist PUBLIC "- //Apple//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/PropertyList-1.0.dtd"> <plist version=.0"> <dict> <key>conversation-idgkey> <integer>246041</integer> <key>date-last-viewed</key> <integer>0</integer> <key>date-received</key> <integer>1361313029</integer> <key>flags</key> <integer>8590195713</integer> <key>gmail-label-ids</key> <array> <integer>6</integer> <integer>2</integer> </array> <key>remote-id</key> <string>277346</string> </dict> </plist> 2 EFTA_R1_01731843 EFTA02566593