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From: Boris Nikolic Sent: Tuesday, August 27, 2013 7:19 PM To: Jeffrey Epstein ([email protected]) Subject: FW: Connecting you PLEASE CALL ME ASAP Sorry - I sent last email before I was done with my writing. Last three weeks it bothered me that you/Larry might be under an impression=that it was not me that found Foundation Medicine but rather we all saw it=at KPBC at the same time. The reason that I knew about Foundation Medicine before KPBC summit is that=l was working with them on getting cancer sample sequenced. Also Eric Land=r told me a while ago. I was updating you and Nathan re their sequencing =fforts (email below) It was me that suggested Larry and Lila that we should also meet FM at KPBC=summit and even pushed for it before and after our meeting. I have a number of emails prior and after that summit. I am happy to forwa=d them to Larry/you if you would like. Perhaps it does not matter right now but I just wanted to clarify. Thank you Boris Original Message From: Boris Nikolic Sent: Monday, September 24, 2012 2:12 PM To: Nathan Myhrvold; Bill Gates Subject: FW: Connecting you HI Nathan, I just checked whether Foundation Medicine (FM) received tumor tissue for a=alysis, but as of today it still did not (see below). They tried everything to speed up but because some (unknown to me) reason, =t is going very slow. EFTA_R1_01743085 EFTA02573180 You can see part of emails trails below • it has been weeks/months that we =re trying to obtain this tissue. I am just afraid that time is not on our side and that a critical window is=closing. Broad people tried to push Kaplan but there is a limit what they can do. Also as I do not know Kaplan and am not involved in her care, it would be g=eat if you can GENTLY see what else can be done that her tumor tissue is f=nally send out. Thank you! Boris Original Message From: Todd Golub Sent: Monday, September 24, 2012 11:42 AM To: Boris Nikolic Subject: Re: Connecting you I just checked, and the team (including CEO of Foundation Medicine) is on t=e lookout for the sample, but it's not yet arrived. I don't think there's =ore we can do. I've already pressed as hard as I feel comfortable. Todd On Sep 24, 2012, at 1:16 PM, Boris Nikolic wrote: > HI Todd, > Sorry for bothering you again with this. Was there any progress of FM ge=ting samples? > As I am not involved in that patient care (nor I am a relative) there is = limitation what I can do to speed up sample delivery to FM. I just learn= that patient is not doing well. > Please let me know if there was any progress and if there are any obstacl=s. > Thank you > Boris Original Messa > From: Todd Golub > Sent: Friday, August 31, 2012 2:48 PM > To: Boris Nikolic > Subject: Re: Connecting you > Boris, > • I've been connecting regularly with Hank Kaplan. I suggested sending samp=e both to Foundation Medicine (for clinical grade testing of a subset of t=e genome) and to the Broad Institute (for research grade testing of the en=ire genome). 2 EFTA_R1_01743086 EFTA02573181 > I touched base with Hank yesterday to see how that was going. He replied =hat a pathologist is working on getting sample to Foundation Medicine. > • I'm not sure if there is interest (or ability) to send more to the Broad =would require some sort of local research protocol). But I'm glad that thi=gs are in motion with Foundation (I've let them know to expect a sample, a=d I'll stay involved with analysis). I think the Foundation test will like=y give most of what's clinically actionable. > • I'll keep you posted on any further progress (though I admit it does seem=a bit slow). > Best, > Todd > On Aug 31, 2012, at 3:26 PM, Boris Nikolic > wrote= » Hi Todd, » It has been few weeks since we talked. » I have been on the road for the most of that time. » I am now back in Seattle and catching up with a number of follow ups. » I am just wondering what is the status of the analysis of the tumor? » Did you have chance to obtain cancer tissue? » Please let me know if I can be of any help. » Thank you » Boris Original Messa e » From: Eric Lander » Sent: Monday, July 30, 2012 2:36 AM » To: Boris Nikolic; Todd Golub » Subject: Connecting you » Boris: » I have spoken with Todd Golub, chief scientific officer of the Broad and=director of our cancer program, about our conversation. » We're glad to help in any way we can. » Todd (copied) will be glad to speak with you -- and to ensure that the r=ght genomic information is obtained and interpreted. » I will be glad to stay in the loop as well. » With best wishes 3 EFTA_R1_01743087 EFTA02573182 » Eric <?xml version=.0" encoding=TF-8"?> <!DOCTYPE plist PUBLIC "-//Apple//DTD PLIST 1.0//EN" "http://www.apple.com/DTDs/Propertylist-1.0.dtd"> <plist version=.0"> <dict> <key>conversation-idgkey> <integer>264599</integer> <key>date-last-viewed</key> <integer>0</integer> <key>date-received</key> <integer>1377631167</integer> <key>flags</key> <integer>8590195713</integer> <key>gmail-label-ids</key> <array> <integer>6</integer> <integer>2</integer> </array> <key>remote-id</key> <string>336183</string> </dict> </plist> 4 EFTA_R1_01743088 EFTA02573183