EFTA02682634

creative Boni Mast bide Tr io MD. MD. !Mellor liarearrt hrulnr, of %e ' kturssehersette Craned H., n 'turtling map Manor frusals fyr 6, for I lssonate Sill. Herren+ I iffirsale **ban S. Fireman, PhD, K id ( It Hunan IL bur Nea. fox:,, ;.., Anne H Phu Marron, f . sc. , •. . orti. in Neurology Nemmlogy Nichular I Lens.. Manna 1.. Pro/cruor • •' '`&03wY Coe 'Ono tine ". Lain, It. HIE), PhD : ' • Synces lough I. 2. . Kennet. of Inil.. Neurology .Mau(:mealflop. lour Chief of Chad Neurology MGD Carter for Aforyhometric Analysts. flintier Statement of Need THE INSTITUTE FOR MUSIC & BRAIN SCIENCE Pllimbdkne Sra,,,ynneWI R.n.n,M 02114 C'. SAN via? al/4e, SS4hef sr. AGa. Executive Summary 1, 1:0,41,1 Fr 6enrl;e Ma tit n. C HE UauJII Ht. MD Sob,' folow in %IPA Cream (Wray L0111. Wads,HAD PIN' i •,rxenµy !OLT Denver grAlf —.= • u u. r• Damn& Director R. Brandon Amid. MD Apollo Nr. rhea! Parton. .Managing Ihreefor Mialati S. Coraaniga. PhD Unroof , • ..f Prrukotogy COX., threclor D.:. %I (..II 1. Swann.. Hanwr. I dn. MT PC &Alec r World fed, , PhD Robb., tee Inn. , I nr.t. wn, MHA Tr/ Officio There is no institution in the world conducting integrated neuroscience, clinical, education, and technology research programs that are devoted to establishing: • Neuroanatomical, Neurochemical, Neurophysiological, Neuroethological, and Genetic bases of humans innate, universal competence for music. • The benefits of music and other forms of controlled auditory stimulation in the treatment of: Surgical Pain, Cancer Pain, Chronic Pain Syndrome, and other types of pain Hypertension, Arrhythmias after Heart Surgery, and other autonomic problems Parkinson's Disease, Paralysis after Stroke, and other movement disorders Attention Deficit Disorder, Alzheimer's Disease, and other cognitive disorders Post-Traumatic Stress Disorder, General Anxiety Disorder, and other emotional disorders Adverse effects of medically-necessary treatments (e.g., Chemotherapy, Radiation Therapy) • The utility of music and other forms of paralinguistic communication for Education of school children who arc in the early stages of language and math acquisition The large proportion of children with developmental language and math disorders who can benefit from paralinguistic cues during learning beyond the early years of language acquisition. Solution Assemble an interdisciplinary team with expertise in cognitive neuroscience, adult and child neurology, early education, music, computer science, and product development from academia, the health care industry, and the private sector in order to: • Found a 49420(3) Private Operating Foundation whose Board members arc affiliated with a major university, major medical center, and venture capitalists/entrencurs .O200871st Institute for Music & Brain Science E FTA_R 1_01997726 EFTA02682634 02008 The Institute for Music & Brain Science Proposal: Florida Science Foundation 20081111 • Conduct basic neuroscience research on neuroanatomical, neurochemical, neurophysiological, neuroethological, and genetic bases of humans' innate, universal competence for music using space and some resources provided by the affiliated university and major medical center and approved by their Institutional Review Boards, and other resources, related overhead, and all research salary and fringe paid by our Foundation • Conduct rigorous, prospective, longitudinal, randomized-controlled clinical trials of infants, children, and adults who are patients being diagnosed and treated at the affiliated major medical center for pain, movement disorders, high blood pressure, emotional disorders, cognitive disorders, chremotherapy, radiation therapy, and other disorders. • Develop and patent treatment protocols and devices in the course of doing the above clinical trials. • Conduct rigorous, prospective, longitudinal, randomized-controlled trials of novel educational tools for teaching reading and math to elementary school children, beginning with reading programs for 1st grade urban schoolchildren that incorporate paralinguistic devices — e.g., prosodic cueing with rhythm, rhyme, and assonance — to enhance word recognition, reading speed, and reading comrehension. • Develop and patient education protocols and tools in the course of doing the above educational trials. • Build the world's first MusicMindBrain Database of behavioral, neural, and genetic data from all healthy and sick infants, children, and adults studied during the course of the above basic neuroscience research, clinical trials, and educational trials. Organization and Expertise The following individuals are committed to participating in the research, clinical, and education activities of the proposed Private Operating Foundation. All that is needed for their participation is salary support for their efforts. A few individuals already have their salary guaranteed and are willing to participate pro bono, though typically their percent effort would be less than 10% because of other commitments. Program in Neuroscience Mark _Jude Tramo, MD, PhD Director, The Institute for Musk & Brain Science Associate Professor of Neurology, Harvard Medical School & Attending Neurologist, Massachusetts General Hospital Steering Committee, Harvard University Mind/Brain/Behavior Initiative Research Affiliate, Research Laboratory of Electronics, Dept of Electrical Engineering & Computer Science, M.I.T. Research Associate, Eaton-Peabody Laboratory of Auditory Physiology, Massachusetts Eyc & Ear Infirmary Songwriter Member, ASCAP Best Doctors in America®/America's Top Physicians® David H. Hubei, MD Founding Board Member, The Institute for Music & Brain Science Nobel Laureate in Physiology or Medicine John Franklin Enders University Professor, Harvard University Founding Member, Harvard Department of Neurobiology 2 EFTA_R1_01997727 EFTA02682635 O2008 The Institute for Music & Brain Science Proposal: I•lorida Science Foundation 20081111 Anne Young, MD, PhD Founding Board Member, The Institute for Music & Brain Science Chief, Department of Neurology, Massachusetts General Hospital Julianne Dom Professor of Neurology, Harvard Medical School Louis D. Braida, PhD Faculty, The Institute for Music & Brain Science Co-Director, Harvard-ALIT. Speech & Hearing Biosciences & Technology Graduate Studies Program Co-Director, Research Laboratory of Electronics, Dept of Electrical Engineering & Computer Science, M.I.T. Henry Ellis Warren Professor, Division of Health Sciences & Technology, I larvard Medical School — M.I.T. Jennifer IL Mekher, PhD Faculty, The Institute for Music & Brain Science Asst Professor of Otology & Laryngology, Harvard Medical School & Massachusetts Eye & Ear Infirmary Founding Director, Auditory Neurology Section, Eaton-Peabody Laboratory of Auditory Physiology, Massachusetts Eye & Ear Infirmary Research Associate, Itlartinos Center for Biomedical Imaging, Massachusetts General Hospital Research Scientist, Auditory Neuroscience Program, The Institute for Music & Brain Science David Kennedy, PhD Faculty, The Institute for Music & Brain Science Director of Programmatic Development, Center for Morphometric Analysis, Massachusetts General Hospital Assoc Professor of Neurology and of Radiology, Harvard Medical School Nikos Makris, MD, PhD Faculty, The Institute for Music & Brain Science Co-Director, Center for Morphometric Analysis, Massachusetts General Hospital Asst Professor of Neurology, Harvard Medical School & Massachusetts General Hospital Katherine B. Sims, MD Director, Neurogenetics Laboratory, Massachusetts General Hospital Assoc Professor of Neurology, Harvard Medical School & Massachusetts General Hospital Winnic Xin, PhD Neurogenetics Laboratory, Massachusetts General Hospital Sarthak Misra, MD Research Associate, The Institute for Music & Brain Science Andrew Dykstra, BS, MS Graduate Student, The Institute for Music & Brain Science Graduate Student, Hansard-ALIT. Speech & Hearing Biosciences & Technology Graduate Studies Program Matthew Serna Undergraduate Student, The Institute for Music & Brain Science Undergraduate Student, Dept of Brain & Cognitive Sciences James Symons Undergraduate Student, The Institute for Music & Brain Science Undergraduate Student, Berklee College of Music Alexis Dale Undergraduate Student, The Institute for Music & Brain Science Undergraduate Student, Undergraduate Student, M.I.T. Dept of Brain & Cognitive Sciences 3 EFTA_R1_01997728 EFTA02682636 O2008 Thy Institute for Music & Brain Science Proposal: 1•lorida Science Foundation 20081111 Program in Heat/b & Medicine Nicholas Zervas, MD, PhD Founding Board Member, 'Mc Institute for Music & Brain Science Higgins Distinguished Professor of Neurosurgery, Harvard Medical School Wiliam Chief of Neurosurgery, Massachusetts General Hospital President ex Ode, Boston Symphony Orchestra Verne S. Caviness, MD, PhD Executive Board, The Institute for Music & Brain Science Joseph & Rose Kennedy Professor of Neurology, Harvard Medical School Chief, Division of Pediatric Neurology, Dept of Neurology, Massachusetts General Hospital Director, Center for Morphomtric Analysis, Massachusetts General Hospital Steering Committee, Harvard University Mind/Brain/Behavior Initiative Jonathan H. Cronin, MD Faculty, The Institute for Music & Brain Science Chief, Division of Perinatology, Massachusetts General Hospital for Children Director, Newborn Intensive Care Unit Associate Professor of Perinatology, Harvard Medical School Margaret Settle, RN, MS Faculty, The Institute for Music & Brain Science Nurse Manager, Newborn Intensive Care Unit Massachusetts General Hospital for Children Fred H. Hochberg, MD Advisory Board, The Institute for Music & Brain Science Founding Director, Music & Medicine Clinic, Massachusetts General Hospital Professor of Neurology, Harvard Medical School Attending Neurologist, Massachusetts Hospital Cancer Center Donald K. Eddington, PhD Faculty, The Institute for Music & Brain Science Director, Cochlear Implant Research Laboratory, Massachusetts Eye & Ear Infirmary Assoc Professor of Otology & l.aryngology, Harvard Medical School Principal Scientist, Research Laboratory of Electronics, Dept of Electrical Engineering & Computer Science, M.I.T. Sydney S. Cash, MD, PhD Faculty, The Institute for Music & Brain Science Instructor in Neurology, Harvard Medical School Asst Attending Neurologist, Epilepsy Unit, Massachusetts General Hospital Leigh R. Hochberg, MD, PhD Instructor in Neurology, Harvard Medical School & Attending Neurologist, Stroke Unit, Massachusetts General Hospital Neurology Consultant, Spaulding Rehabilitation Hospital Karen Furie, MD Associate Professor of Neurology, Harvard Medical School Attending Neurologist, Stroke Unit, Massachusetts General Hospital Emad Eskandar, MD, PhD Associate Professor of Neurosurgery, Harvard Medical School Attending Neurosurgeon, Massachusetts General Hospital 4 E FTA_R 1_01997729 EFTA02682637 O2008 The Institute for Music & Brain Scitnor Proposal: Florida Science Foundation 20081111 Tamara Chuprina Research Assistant, The Institute for Music & Brain Science Program in Education Peter B. Rosenberger, MD Faculty, The Institute for Music & Brain Science Associate Professor of Neurology, Harvard Medical School Director ex officio, Learning Disorders Program, Massachusetts General Hospital David Gow, PhD Faculty, The Institute for Music & Brain Science Asst Professor of Neurology, Harvard Medical School & Massachusetts General Hospital Research Affiliate, Speech Communication Group, Research laboratory of Electronics, Dept of Electrical Engineering & Computer Science, Karen Littman Consultant, The Institute for Music & Brain Science CEO, Morphonix, Inc, Sausalito, CA Jeanne Bamberger, PhD Consultant, The Institute for Music & Brain Science Professor Emeritus of Music & Urban Education, University California at Berkeley Caitlin Van Ness, BA Consultant, The Institute for Music & Brain Science Teach America, Bronx, NY Program in Technology R (dr D Jeffrey Epstein Advisory Board, The Institute for Music & Brain Science President, Florida Science Foundation Jack M. Gill, PhD Advisory Board, The Institute for Music & Brain Science Senior Partner, Vanguard Ventures, Palo Alto, CA President, The Gill Foundation James L. Singleton, MBA Advisory Board, The Institute for Music & Brain Science Managing Director, Pillar Capital, LP Brandon Fradd, MD Managing Partner, Apollo Medical Partners Advisory Board, The Institute for Music & Brain Science Program in Music Robert S. Freeman, PhD Board Chairman, The Institute for Music & Brain Science Regents Professor and Whilom Dean of Finc Arts, University of Texas at Austin Director ex officio, Eastman School of Music, Rochester University 5 EFTA_R1_0 1997730 EFTA02682638 O2008 The Institute for Music & Bruin Science Proposal: Florida Science Foundation 20081111 President ex types, New England Conservatory of Music Sir George Martin, CBE Advisory Board, The Institute for Music & Brain Science Founding President, AIR Studios Producer, The Beatles Trustee, National Academy of Recording Arts & Sciences Caroline Bienstock, JD MBA Advisory• Board, The Institute for Music & Brain Science COO, CarlinAmerica Music Bernie Krause, PhD Advisory Board, The Institute for Music & Brain Science President, Wild Sanctuary, Inc., Glen Ellen, California Producer Funding Requirements Funding requirements are calculated on the basis of 1) annual operating costs provided by an endowment yielding 4% annually; and 2) start-up funds that cover the first year of operating costs plus equipment and supplies needed for the first year. No "cost-of-living" or inflation increases were included in these estimates, nor do they include projected costs for equipment repairs, upgrades, new software etc. This reflects, in part, the fact that we will continue to apply for funding to federal and private sources for funding and that we will continue to try to increase the size of our Board, particularly the number of members from the business community who can help us to grow our annual giving fund. 1. Endowment = $9.625M At 4% per year, this would provide for an Annual Operating Budget of $385k, to be distributed as follows: Personnel = $250,000 Equipment = 25,000 Supplies = 25,000 Travel = 10,000 Overhead = 75,000 $385,000 2. Start-Up = $785k Year 1 Operating Cost = $385k Electroacoustics (ERP) = $200k Psychoacoustics = $25k Auditory fMRI = $25k Microelectrode = $25k Neurochemistry = $25k Quantitative Morphometry = $25k EFTA_R1_01997731 EFTA02682639 02008 Thy Institute for Music & Brain Science Proposal: Florida Scicncc Foundation 20081111 Genetics = $25k Autonomic electrophysiology = $25k Immunochem/Endocrin = $785k 3. TOTAL = $10.41 M EFTA_R1_0 1997732 EFTA02682640