From: Lesley Groff <1

From: Lesley Groff <1 To: Joseph Thakuria Cc: "Dr. George Church" <1 Subject: Re: Jeffrey Epstein Date: Sat, 21 Sep 2013 12:47:13 +0000 Morning JOe...just thought I would follow up on the email I sent you the other day...Jeffrey is asking if there is any update on his genome! Could you let me know? Thanks so much...I do know you are tremendously busy! Lesley Assistant to Jeffrey Epstein On Aug 1, 2013, at 8:03 AM, Joseph Thakuria > wrote: Hi Lesley, Jeffrey's skin biopsy resulted in several successful, viable fibroblast cultures. Those cell lines are now stored in liquid nitrogen and slated for iPS cell line ("adult stem cells") creation. Essentially, this process requires several culture passages, and reiteration of picking out the right colony for further passages. Success rate of generating iPS cells is relatively high now but the process still takes several months. On the DNA side of things, I'm working on getting Jeffrey's sample into the current queue. If it makes it, we're probably looking at about 2 months turnaround time until whole genome data. Let me know if I can help with other questions. Best, Joe Joseph V. Thakuria, MD, MMSc Medical Genetics and Metabolism Attending Physician Director, MGH Stickler Syndrome Program Medical Director, Personal Genome Project Harvard Catalyst CRC Protocol Review Committee MGH Center for Human Genetics Research Massachusetts General Hospital 185 Cambridge St., Rm. 2222 Boston, MA 02114 email: [email protected] The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.orq/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail. EFTA00383091 On Thu, Aug 1, 2013 at 7:43 AM, Lesley Groff wrote: Good morning George and Joe. Jeffrey requested I check in and see how things are progressing with his genome. Could you please advise? Thank you, Lesley Assistant to Jeffrey Epstein Sent from my iPhone EFTA00383092