HARVARD

HARVARD MEDICAL SCHOOL Genomics and Synthetic Biology Research Fund Terms of Gift EFTA00583251 GENOMICS AND SYNTHETIC BIOLOGY RESEARCH FUND AT HARVARD MEDICAL SCIIOOL TERMS OF GIFT Gift This generous gift of $2,000,000 from Leon D. Black and/or the Leon Black Family Foundation ("the Donor"), to the President and Fellows of Harvard College ("Harvard"), a Massachusetts educational and charitable corporation, creates a current-use fund to be designated the Genomics and Synthetic Biology Research Fund ("the Fund") at Harvard Medical School. Use of Fund The Fund will be under the direction of George M. Church, PhD, and used to support research at HMS that may include analysis of personalized genomics, microbiomics, metabolomics, and other omics; development of gene therapies; engineering cells resistant to viruses; aging reversal; humanized animals for research and organ transplants; biosensors for optimization of chemical manufacturing; and regulating complex biological circuits. Pledge Payment Schedule The Donor hereby irrevocably pledges and promises to pay $2,000,000 to Harvard Medical School in two equal installments according to the schedule below: No Later Than Dollar Amount December 31, 2014 $1,000,000 September 30, 2015 $1,000,000 Administration of Fund Harvard Medical School will have responsibility for the administration of the Fund. The investment, administration, and distribution of the Fund shall be accomplished in accordance with Harvard University policies governing endowment and certain other institutional funds, which may be amended from time to time. Under current policies, a portion of the amount made available for annual spending may be applied to defray direct and indirect facilities and administrative costs. 21 Harvard medical school ®President and Fellows of Harvard College EFTA00583252 Alternative Use If George M. Church, PhD, retires or otherwise departs from Harvard University, is no longer considered by Harvard University to be an active faculty member, or no longer directs research at Harvard University, the Fund will continue to support research at HMS consistent with the terms herein. If, at some future date, in the opinion of the Dean of the Faculty of Medicine, the Fund can no longer be expended or administered per the terms herein, it may be used for other purposes as consistent as possible with the intention of the Donor. Recognition The Donor authorizes HMS and Harvard University to list the names "Leon D. Black MBA '7S" and "Leon Black Family Foundation" and the category of this support in any of their publications or press releases. Amendment This agreement can only be amended by a written document agreed to and signed by the Parties. DONOR Leon D. Black MBA '75, individually and as President of Leon Black Family Foundation Donor HARVARD MEDICAL SCHOOL Date: Jeffrey S. Flier, MD Date: Dean of the Faculty of Medicine PRESIDENT AND FELLOWS OF HARVARD COLLEGE Denise A. Gorayeb Date: Recording Secretary 3I Harvard medical school ®President and Fellows of Harvard College EFTA00583253