The Foundation

The Foundation for Medical Research in short.. . Created in 1947 by famous researchers, one of which was Prof. Jean Bernard. FONDATION RECHERCHE MEDICALE Recognized as Public Utility Fondation since 1965 - Being independent, it receives no French or European funding. Objective: contributes to the development of innovative and pioneering public research, and accelerates the advances in fighting against all illnesses. Support between 400 and 450 new research studies, which requires c45 million in funding each year. Stephanie Climent-Grandcourt: Director of Philanthropy and Trust Tel. 01 44 39 75 96 • stephance.clement-grandcourtef rm.org EFTA00592853 A unique position at the core of research The Foundation is a major actor in the field of medical research. Through the force of its financial support and intimate knowledge of research requirements and priorities in public health, the Foundation works effectively to respond quickly to the needs of research teams. The Foundation supports research for all pathologies. It is involved in all areas of research: cancer, neurologi- cal, cardiovascular, and infectious diseases and promotes major advancements in health. DONOR GUARANTEE to have a significant impact on the fight against disease, and provide support to work that matches urgent public health issues. the possibility to choose the pathology and project to be financed. The Foundation does not carry out research. It selects and finances the most promising French research teams tat the INSERM, at the CNRS, at universities, in hos- pitals'. via a high-level scientific advisory board made up of researchers and doctors (30% of the 1.500 projects that are considered are eventually selected). the assurance of funding highly-promising research with excellence as the only criteria for selection. The Foundation oversees the progress of all of the work that it finances. The staff at the Foundation's Scientific Department carries out scientific and financial monitoring. follow-up on the impact of the donation; the possibility to meet with the researchers; information on research progress. Vehicles of philanthropy available to the donor: Support for a research team or an emerging researcher ElOk (€2,500 after a wealth-tax deduction) Creation of an Award on behalf of the donor E20k/year for fi il te years (€5.000/year after a wealth-tax deduction) Creation of a sheltered foundation (see inset) €50k/year for three years (E12,500/year after a wealth-tax deduction) Stephanie Clement-Grandcourt: Director of Philanthropy and Trus: Tel. 01 44 39 75 96 • stephanie.ctement-grandcourtefrm.org EFTA00592854 Customized asset management services: A team of legal and financial experts is at the donor's disposal, along with their advisors, in order to optimize the legal aspects of their commitment, according to donor wishes. Reminder of tax deductions: LiT I 75% deduction of the amount of the donation from the wealth tax (with a maximum of E50k1. Amount of the wealth Amount of the Amount of Amount of the Actual cost tax to be paid before donation to the the wealth-tax wealth-tax after of the the donation FRM 'Foundation for deduction tax deduction* donation Medical Research) 15 000 E 20 000 E 15 000 oe 5 000 € 30 000 E a 40 000 E 30 000 € 0€ 10 000 € 50 000 E 66 667 € 50 000 E 0€ 16 667 € •To reduce the wealth tax to 0, the amount of the tax must be divided by 0.75, which gives you the amount of the donation. The possibility to create sheltered foundations: • Choice of the name and the foundation's focus area. • The same tax benefits as for donations to the Foundation. • Choice of research teams to be funded. • Organized meetings with funded researchers. • Accurate tracking of your philanthropic investment. • For individuals: a minimum financial commitment of €50K/year for three years (€12.500/year after a wealth- tax deduction). Use of the donations: Out of E100 from public donations in 2014: ial missions el 5,4 Fundraising 04,1 Running costs* *the running costs are covered by the Foundation's financial proceeds. Stephanie Clement-Grandcourt: Director of Philanthropy and Trust Tel. 01 44 39 75 96 • stephanie.clement-grandcourtefrm.org EFTA00592855 Meeting exceptional researchers... Jules Hoffmann, Nobel Prize in Medicine in 2011 Foundation for Medical Research Grand Prize in 2004. Francoise Barre-Sinoussl, Nobel Prize in Medicine in 2008 Jean Weissenbach, CNRS Gold Medal in 2008 and Foundation for Medical Research Grand Prize in 2007. * Documentation available upon request • Brochure about the Founda- tion's sheltered foundations • Brochure about the 2016 wealth tax Major advances in health issues and the fight against disease... I • The measles vaccine: the new anti-cancer weapon At the Nantes-Angers Cancer Center Research, INSERM Director of Research Marc Gregoire's team is working on an inventive application of the measles vaccine: treating a severe form of cancer caused by exposure to asbestos. €249K in funding • Alzheimer's Disease: the hope for gene therapy At the Atomic Energy Commission, INSERM Director of Research Nathalie Cartier is fighting the progres- sion of Alzheimer's Disease through gene therapy (a method using genes and the information carried wit- hin them to treat the disease'. Following convincing results in mice, her team is preparing the move to clinical trials. €400K in funding • Cancer of the esophagus: constructing biosynthetic esophagi to re 'lace dama.ed orians Jerome Larghero, in charge of the Cellular Therapy Bu- siness Unit at Satin-Louis Hospital, and his team are wor- king on creating esophageal segments through tissue engineering. A world first, this technique could constitute an attractive alternative to current procedures 'grafting from the patient's stomach or from segments of their colon), which today presents the risk of post-operative complications or death. €170K in funding Procedures and verification to insure you that your donation will be put to good use: certification of annual accounts by an independent Auditor, sending all financial statements to all donors, • organization of annual lunches to present the financial statements, licensed by the Committee of the Charter for Trust in Fundraising in France. Stephanie Clement-Grandcourt: EFTA00592856