DS9 Document EFTA01113642A Genetic Cause for Multiple Sclerosis is Identified by Oxford University and funded In
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efta-efta01113651DOJ Data Set 9OtherNowak project
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Nowak project
1. Linear case:
xi' = (1-q)E r., a„x„ - (qa, + di)x,
xfig =
- Olan +
xn-
y'= by -dy.
Eigenvalue condition for the x equation:
1=
Tf n
qak
nXi
(qak + dk))
Note that X > 0 requires that
v n. clak
I
q
1 I k=I (qak +4)
(1.2)
The condition A.> b-d is needed for growth faster than that of y. This condition reads
I - q v
clak
> 1 .
q 4d.ai rik=l(b-d+ Nak + dk
(1.3)
In the case when ak = a and dk = d is constant, then the condition in (1.1) asserts
that 1 = La
g En ,11 with n= qa(X + qa + d)". This is to say that 1-3— =
-ri) and so n
- q
= q. Thus, X + qa+ d = 2qa and so X = (1 -q)a - d. Growth faster than the y-model
requires (I -q)a > b which is maybe expected.
Martins `system with food' on page 2 at equilibrium e = d/b gives the linear
instability condition that is identical to (1.2) with the replacement q
z*q. This
understood, I will address the remaining questions on the bottom of page 2 with e = 1.
a) Neutrality
Martin suggests considering the case dk = d in which case the condition X = b- d
reads
v n . qak
=
iLinZi I
(qak + b)
'
(1.4)
Martin claims that this condition is obeyed if ak = k b. In the latter case, the condition in
(1.4) reads
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•
q
L V ind n
(qk+ I) - ,
(1.5)
To verify that this is indeed the case, introduce for the moment rt to denote 1/q.
What is written in (1.5) is equivalent to the assertion that
L rrn
k
I
iza Lk.' (IC +1) -
11-I
(1.6)
A given term in this sum is equal to
11rr
to
dt .
Jo (ti-tr+1+1
(1.7)
as can be seen using n successive integration by parts. This being the case, interchange
the sum and the integral. The result on the left side of (1.6) is then
TI
E (
f (l+t)2441
ti-t r dt •
0
(1.8)
The sum in the integrand is geometric, and what is written above is equal
11 sdt
- f
lr
0+q4.4
0+0..dt •
0
(1.9)
The right hand integral is indeed equal to 1 1_
b) ak = b for k < m and ak = a for k > m
Martin asks for the case ak = b fork < m and ak = a for k a m with a > b. I assume
again that all dk = d. In this case, the left hand side of (1.4) reads
t (14
E
isatin ci ii+
+ ((qaqa+b))mIrkzo((qaq:b)) k
(1.10)
Evaluating these sums gives the instability condition
caq:b)m-I
((q+q „r
q
-I
•
c) ak is a rational function of k
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The next case Martin asks about is that where ak = (cok - c,)/(k + c2) where the
constants are chose so that b = (co - cl)/(1 + c2). The neutrality condtion in (1.4) reads
L-sz fr
q(cok -c1)
q
Au
kml(qco+b)k +(bc2 -qci ) — 1 •
(1.12)
This can be rewritten as
= 1 ,
(1.13)
(leo
ci
d (4— bc2 ' 4`' The n'th term in the sum in (1.13) can be
where y = cietp0
=
an v
qco + b •
written as
tn- Ct
Fr
0+00. 4 dt where p = j
t-a04P dt .
(1+
(1.14)
This understood, interchange the integral with the sum to rewrite the sum in (1.13) as
ir
t
+titt-
1+
a
7P J
-c
nzo(ar dt =
0 (1
(
0 -100 dt.
ci 0+04
(1.15)
The stability condition in (1.12) can be restated as
—
t -a,„ dt .
qcg oc°+b J0 (i-Ft9(1+(1-y)t)dt > 0 q 0 (1+t)rF
(1.16)
According to Gradshteyn and Ryzhik, (Tables of integrals, series and products; Enlarged
edition, I. S. Gradshteyn and I. M. Rhyzik; Academic Press 1980), these definite integrals
can be expressed in terms of two special functions, these denoted by B (this being the
'beta function' or `Euler's integral of the first kind') and F (this being `Gauss'
hypergeometric function'). In particular, Equation 9 in Section 3.197 writes
CO
•
-1
at-a
dt -(I yrrri B(a+ (3,1-a) F03,0(4(3;1+13;10.
0 0+01.(1+011 )
OD
• .1
t-a
0+0,4 dt= BOx+(3,1-a) Fa3,a+I3 ; 1+(i;0) .
(1.17)
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For what it is worth, the special functions B and F are defined respectively in Sections
8.38 and 9.10-13 of Gradshteyn and Ryzhik.
d) Interpreting the instability condition
Martin asks for the meaning of the condition that
I -9 v
n.
Sac
>1
q
.
1.12111 k.1 (qak + b)
(1.18)
Setting a k = (qacika+1 b) , this is equivalent to the condition that
a, + ay; + a la 2a 3 + •
> ATI .
(1.19)
What follows is a thought about an interpretation: Looking at the equation for xkm, I can
think of cc., as the probability of creating some xk given xk.I. This understood, a l is the
probability of having x2 given xi, then ccia 2 is the probability of x3 given ; and a lcc2a5 is
the probability of ; given xi, etc. The sum on the right can be thought of as a sum of
conditional probabilities.
I shall think more about this as a path to an interpretation of (1.19).
e) Other forms of density regulation
I haven't had time to consider these yet.
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