EFTA Document EFTA01620806

Platform: iMessage Timezone: UTC+0000 • 0 O Cool Experiment Put plants on Prozac 04:51:11 am 2018/03/06 2018/03/11 https://en.wikipedia.org/wiki/Holonomic_brain_theory 0 12:11:48 am 2018/03/13 http://www.plantbehavior.org/ Sent an attachment Filename: 7520950E-6AD8-4361-962E-0D3330766E59.pluginPayloadAttachment Path: 7520950E-6AD8-4361-962E-0D3330766E59.pluginPayloadAttachment 04:17:35 am EFTA01620806 O O Read some of these 04:17:35 am 2018/03/15 vi 05:57:07 am https://www.usatoday.com/story/tech/2018/03/14/b i I l-gates-meet-tru m p-white- house/427044002/ • 04:13:18 am Crazy 04:13:18 am yyup 09:06:28 am • • EFTA01620807 2018/03/17 https://www.nytimes.com/2018/02/02/science/plants-consciousness-anesthesia.html O fl 06:17:31 pm Leaf from my bonsai tree vs Live brain 2018/03/24 Yes 07:35:22 pm EFTA01620808 OS:34:12 dill https://www.amazon.com/Scale-Universal-Innovation-Sustainability- Organisms/dp/1594205582 Sent an attachment Filename: 93E3A033-DBBD-4DE1-9D6D-7E85AA83579E.pluginPayloadAttachment Path: 93E3A033-DBBD-4DE1-9D6D-7E85AA83579E.pluginPayloadAttachment Size: 17 KB Type: image/vnd.microsoft.icon SC ✓Prime 05:37:57 ar. EFTA01620809 O O Read this book 05:37:58 am How was plant talk 01:08:34 am 2018/03/30 2018/04/01 GREAT GREAT 10:48:27 am Great 01:13:51 am Mitochondria... Looks like it works in spinal cord ischemia too. Brain for sure. Heading to Boston in about 10 days to meet w collaborator (McCully) and also see Ed Boyden Really neat. Seems to work best endovascular. 07:51:27 pin Our research team is me, Yashar Kalani at UVA and McCully at Harvard. Last S months experiments all Good. Planning next few months. Got another grant to continue work. Not sure what's next. 07:52:39 pm http://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.693.10 EFTA01620810 Sent an attachment Filename: 1EE01CCC-CC D3-4A20-8769-AFE42AD7681E.plugi nPayloadAttach me nt Path: lEE01CCC-CC D3-4A20-8769-AFE42AD7681E.plugi n PayloadAttachment Size: 894 bytes Type: image/vnd.microsoft.icon 07:54:26 pm 2018/07/22 https://www.nature.com/articles/s41419-018-0765-9 n POLG1135 a NOW SAPIENS PAM TROGLODYTES RAMS NORVEGICTIS NPS ITOSCIILOS EDI0P0S LAGVIS S. Mil/15'AL NtOROSPORA CRASSA C d i ICTSRVERVV0SSAVDYIJILKLVANCELKITFAI WRFC I S I EDEVRYLVREEDRYRAALA IITSRVINVV0SSAVDTLNINCLVANIGILFZETAI NMI S I RDEVRYLVRCEDRYRAALA IITSRVITINVQSSAVDTLAUGNANICHLTEEFAIGGRECISINDEVICTLVREEDATRPJJA ITSRVISYNATSSAVDTLIGKLVAIEGILFEETAI WRFC! S I RDEVRTLVREEDRYRAALA ITS RVIINVYPSSAVDTLII LMINAIIINSFEAYDI DGRFCI S I NDLVRTLVHS KDRTRAALA LDStt I EMI 12SSCVDTLII LLCCS/LIT I IKIMILEARLCI S I IIDEIRPLVSEEDITYLUMA LTSRI MAI OSSEVDTLJILL I IANDYLIRRITILACRLAITVIIDEIRTLASEPDAYRVANA Moon II Bkl=pternew Pt *TOW (I) Mouse I IIEPOLG1 (231bp) IMIGFP (197bp) nil DNA ,orpreler rm , V.,ild,lype GFP Bright field (II) Mouse II (Ill) Mouse III blart7A (330bp) li=POLG1 (231bp) rtTA (330bp) GFP (197bp) • Dox POLG1(107bp) 82M (177bp) POLGI rtTA 03:15:39 pm EFTA01620811 Mitochondria O 03:15:39 pin Yay 03:28:10 pm We are working on it on brain. A little harder. But did you see the NYT Story in heart mitochondria last week? 03:28:52 pin We will end up being right if we do exactly as plants do (analogue not exact) O 03:31:41 pin Yes, how does it work in plants 03:31:46 pm They move healthy mitochondria from One place to another 03:31:59 pm They don't modify the DNA that's just stupid 03:32:06 pin It's really expensive energetically for plants be they have to move across a cell wall - so you know it has to be important 03:32:40 pin It's just batteries 03:33:01 pin EFTA01620812 Plug and play 03:33:04 pm This is a plant curing it's own Alzheimer over a few hours O • t: - :t• . d • 03:33:46 pm How cool 03:34:12 pm Root cell w plaques caused by soil stress reversed by shifting motochondria 03:34:16 pm In this case too much aluminum which is nasty to plants in soil and also humans 03:34:41 pm EFTA01620813 THe other thing plants can do is shift their metabolic pathways around their available resources Like glutamate / glutathione shift Humans can't we always shift to glutamate and fry our neurons 03:35:39 pm I think for that one it is sulfur storage (glutathione) that humans don't do well O 03:36:01 pin How do they shift. Enzymes? 03:37:21 pm  Sent It's just energetics 03:37:30 pm (For plants) Much easier when you have stored catalysts 03:37:45 pm It's like a seesaw 03:37:58 pm It can't only ever do one thing based on available resources That's how they age and die is when those resources get depleted Using by getting messed up w stuff in soil 03:38:36 pm Usually by getting messed up w stuff in soil 03:38:45 pm EFTA01620814 https://www.sciencedirect.com/science/article/pii/S0736453906800164 03:44:22 pm httpSfinph.OMMelibrary.Wiley.COM/dOlipdf/10.1111/Vh.13221 03:45:20 pm Sent an attachment Filename: nph.13221.pdf Path: nph.13221.pdf Size: 858 KB Type: application/pdf O e-N 03:45:25 pin 2018/07/29 I take patient requests very seriously EFTA01620815 O en 07:02:53 pm ../ Read EFTA01620816