EFTA Document EFTA01922847

To: Lesley Grof From: Jeffrey E. Sent Thur 6/5/201411:01:59 PM Subject Re: Jeffrey Epstein weekend or monday afternoon On Thu, Jun 5, 2014 at 3:31 PM, Lesley Groff wrote: Would you like to schedule a call with Joe? Tomorrow or over the weekend works for him. Sent from my iPhone Begin forwarded message: From: Joseph Thakuria Date: June 5, 2014 4:36:50 PM EDT To: Lesley Groff Cc: Richard Kahn Subject: Re: Jeffrey Epstein OK, let's set up the call for the other topics (a and b above). We wouldn't just do his bioinformatic analyses and not the rest. le, the bioinfo platform will cost the same for 1 person vs 100 or more once the system is purchased. But I'll look into other funding for this. Obviously (and hopefully this was clear), Jeffrey's enrollment in the study has absolutely no bearing on whether he helps fund the bioinfo or not. I wouldn't do that to him. He's in regardless. As we look to fund this piece, it just seemed worth asking. Thx, Joe On Thu, Jun 5, 2014 at 4:13 PM, Lesley Groff wrote: Hi Joe...Jeffrey says he wants to do his first and then after this, he would be happy to fund the others... On Jun 5, 2014, at 3:46 PM, Joseph Thakuria wrote: EFTA_R1_00367021 EFTA01922847 Thanks - this is research so nothing can be 100% certain ,but, to my knowledge, our study will have greater NGS data privacy than any other similar medical genomics research effort. Afterwards, if Jeffrey still wanted to share his data through the PGP or other efforts, we could help facilitate that. Best, Joe On Thu, Jun 5, 2014 at 3:40 PM, Lesley Groff wrote: Hi Joe! What fabulous news! I will pass this along to Jeffrey and Rich (our accountant) Hopefully Jeffrey can call you very soon—! I'll see if I can get a possible day/time...Lesley On Jun 5, 2014 at 3:34 PM Joseph Thakuria wrote: Hi Lesley, Sorry for the delayed response. We just got word from the IRB and we're finally ready to push forward with the YPO study. Lesley, I wanted to discuss a couple things with Jeffrey by phone at his convenience including: a) getting a whole genome through Illumina puts him a little bit outside of the workflow pipeline for the YPO project. Ie, those participants are paying $1000 each and will be getting their exomes sequenced through Ambry, a thumbnail drive of their compressed genomic data, and an annotated report of 56 ACMG gene hits. I think it's worth getting him into this queue as well so he goes through the same pipeline as the YPO folks and others in our study. Last time I discussed with him he definitely wanted a whole genomes through Illumina for 411,000 (which is still fine) but would he be interested in also getting the SI000 exome to also go through the normal pipeline? Although the exome data should be redundant with the whole genome data, I think it's worth it for the thumbnail drive and the ACMG gene summary. We'll also be able to check for concordance between the 2 datasets. b) Jeffrey has samples (including fibroblast cell culture from his skin biopsy) at HMS. Do I have his permission to request these EFTA_R1_00367022 EFTA01922848 samples from the PGP for inclusion in the YPO study? (The samples can be used for both studies if he wishes.) Our YPO study may need a self-collected saliva sample for which I can mail him a kit. So, I wanted to discuss these sample issues with him as well. c) Lastly, we actually still need some bioinformatic and genetic counselor support for the YPO study - not just for his sample but all of our 80 plus YPO study subjects (from the Austin chapter). As I mentioned, all 80+ have already paid $1000 each for the sequencing but we still need to cover bioinformatics and a part-time GC for all particpants. In the past, months ago now do to the IRB delay, Jeffrey was generous enough to offer to pay for sequencing of YPO members. Since that's already covered, I'm wondering if he would consider donating financial support for bioinformatic infrastructure for this study. I'm available to discuss later this evening. Tomorrow and this weekend are also relatively open for a brief call. My cell is Thanks in advance for passing on this message. We're excited to finally be moving forward with our innovative study. Best, Joe On Thu, May 29, 2014 at 1:29 PM, Lesley Groff wrote: Hello Joe! Hope you are well and enjoyed the Memorial Day weekend...Jeffrey is asking if you have been able to submit his sample as of yet? Can you let me know where we stand? Thanks, Lesley EFTA_R1_00367023 EFTA01922849 please note The information contained in this communication is confidential, may be attorney-client privileged, may constitute inside information, and is intended only for the use of the addressee. It is the property of JEE Unauthorized use, disclosure or copying of this communication or any part thereof is strictly prohibited and may be unlawful. If you have received this communication in error, please notify us immediately by return e-mail or by e-mail to [email protected], and destroy this communication and all copies thereof, including all attachments. copyright -all rights reserved EFTA_R1_00367024 EFTA01922850