EFTA Document EFTA02104907

To: Joe Thakuria Cc: Richard Kah Fran: Sent Thur 6/5/2014 8:13:28 PM Subject Re: Jeffrey Epstein Hi Joe...Jeffrey says he wants to do his first and then after this, he would be happy to fund the others... On Jun 5, 2014, at 3:46 PM, Joseph Thakuria wrote: Thanks - this is research so nothing can be 100% certain ,but, to my knowledge, our study will have greater NGS data privacy than any other similar medical genomics research effort. Afterwards, if Jeffrey still wanted to share his data through the PGP or other efforts, we could help facilitate that. Best, Joe On Thu, Jun 5, 2014 at 3:40 PM, wrote: Hi Joe! What fabulous news! I will pass this along to Jeffrey and Rich (our accountant) Hopefully Jeffrey can call you very soon—! It see if 1 can get a possible day/time...Lesley On Jun 5, 2014, at 3:34 PM, Joseph Thakuria wrote: Hi Sorry for the delayed response. We just got word from the IRB and we're finally ready to push forward with the YPO study. I wanted to discuss a couple things with Jeffrey by phone at his convenience including: a) getting a whole genome through Illumina puts him a little bit outside of the workflow pipeline for the YPO project. Ie, those participants are paying $1000 each and will be getting their exomes sequenced through Ambry, a thumbnail drive of their compressed genomic data, and an annotated report of 56 ACMG gene hits. I think it's worth getting him into this queue as well so he goes through the same pipeline as the YPO folks and others in our study. Last time I discussed with him he definitely wanted a whole genomes through Illumina for —$11,000 (which is still fine) but would he be interested in also getting the $1000 exome to also go through the normal EFTA_R1_00718209 EFTA02104907 pipeline? Although the exome data should be redundant with the whole genome data, I think it's worth it for the thumbnail drive and the ACMG gene summary. We'll also be able to check for concordance between the 2 datasets. b) Jeffrey has samples (including fibroblast cell culture from his skin biopsy) at HMS. Do I have his permission to request these samples from the PGP for inclusion in the YPO study? (The samples can be used for both studies if he wishes.) Our YPO study may need a self-collected saliva sample for which I can mail him a kit. So, I wanted to discuss these sample issues with him as well. c) Lastly, we actually still need some bioinformatic and genetic counselor support for the YPO study - not just for his sample but all of our 80 plus YPO study subjects (from the Austin chapter). As I mentioned, all 80+ have already paid $1000 each for the sequencing but we still need to cover bioinformatics and a part-time GC for all particpants. In the past, months ago now do to the IRB delay, Jeffrey was generous enough to offer to pay for sequencing of YPO members. Since that's already covered, I'm wondering if he would consider donating financial support for bioinformatic infrastructure for this study. I'm available to discuss later this evening. Tomorrow and this weekend arc also relatively open for a brief call. My cell is Thanks in advance for passing on this message. We're excited to finally be moving forward with our innovative study. Best, Joe On Thu, May 29, 2014 at 1:29 PM, wrote: Hello Joe! Hope you arc well and enjoyed the Memorial Day weekend...Jeffrey is asking if you have been able to submit his sample as of yet? Can you let me know where we stand? Thanks, EFTA_R1_00718210 EFTA02104908