Ackrell Capital Cannabis Investment Report – Technical Overview of Cannabis Genetics (Dec 2017)

ACKRELL Z~APITAL Cannabis Investment Report | December 2017 for social anxiety disorders containing CBD, limonene and linalool; and sleeping medicines combining CBD, THC, caryophyllene, linalool and myrcene. Genetics and Propagation Selective breeding and other botanical techniques are being used to develop cannabis varieties with desired profiles of compounds, and scientists are developing tools to synthesize isolated cannabinoids in laboratory settings in order to study cannabis at the genetic level. For example, the first mapping of a cannabis genome was completed in 2011 by a team of Canadian botanists, led by Jon Page from the National Research Council Canada and Timothy Hughes from the University of Toronto, who sequenced 30,000 genes in a sativa variety named “Purple Kush.” Olivetolic acid Aromatic G Prenyltransferase | — Cannabigerolic acid Lat THCA Synthase/ = = —_ \CBDA Synthase on Chen = bh Ae-THCA CBDA | Non-enzymatic conversion (-CO,) Oh Oe CBD A®-THG Cannabis Genome Genetic copies, or “clones,” of cannabis plants are generally produced using two methods, “clone clipping” and micropropagation, or “tissue culture.” Clone clipping involves cutting a growing tip from a cannabis plant that is several inches long and inserting the cut tip into a grow- ing medium, where it then grows into a new plant. Tissue culture involves taking a small tissue sample (which may even be a single cell) from a plant and growing it temporarily in a sterile nutrient solu- tion before transferring it to a permanent growing medium. Controlling cannabis plant genomes is expected to be an important intellectual property issue in the cannabis industry (at least one U.S. pat- ent has been issued for a strain of cannabis). 28 © 2017 Ackrell Capital, LLC | Member FINRA/SIPC HOUSE_OVERSIGHT_024664