EFTA Document EFTA01459575

Equity Sectors An "Appreciation" for Innovation and Demographics Record Orphan Drug Approvals Genome Costs Decreasing 6. 50. 40 30 10 a_..i g §§ §E §§§ili R RRR RRRRRR eFDA Orphan Drug Approvals by Year Footnotes Data as of Dirember 31. 2014. Source: FDASlog, Deutsche Bank Wealth Management Six Year Challenge?* 45 40 35 30 25 20 15 10 5 s- o 41 - T 1 2011 2012 2013 • Heaftncare • S&P 500 2014 2015 Footnotes: Data as of December 31. 2015. 'Annual total return, He